Synthetic Penicillin

Amoxycillin: a new semi-synthetic penicillin.

Amoxycillin (alpha-amino-p-hydroxybenzylpenicillin) is a new semi-synthetic penicillin with a broad spectrum of antibacterial activity similar to that of ampicillin. Penicillin-sensitive strains of staphylococci, streptococci, and pneumococci were sensitive to concentrations of 0.1 mug or less of amoxycillin/ml. Strains of Haemophilus influenzae were inhibited by a level of 0.5 mug/ml, and most...

BENZYL PENICILLIN, BENZYL PENICILLIN India, BENZYL PENICILLIN manufacturers India

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Penicillin

By SIR ALEXANDER FLEMING, F.R.C.S., F.R.C.P., F.R.S. from the Inoculation Department, St. Mary's Hospital I HAVE in the last few years received a certain number of honours, but none has touched me more than the invitation to deliver the Robert Campbell Oration for thtis year in Belfast. I did not know Robert Campbell personally, but I have read much about him and have appreciated my great misfo...

A novel penicillin acylase from the environmental gene pool with improved synthetic properties

A new penicillin acylase was isolated by cloning and functional screening of DNA isolated from a sand soil enrichment culture. Sequence analysis of this enzyme, PAS2, revealed homology to a group of prominent penicillin G acylases, including the intensively studied enzyme of Escherichia coli ATCC 11105. Accordingly, PAS2 was found to be an Ntn-hydrolase with an N-terminal serine as the catalyti...

Penicillin Therapy